Effect of hyperbaric oxygenation on carbohydrate metabolism protein synthesis in the myocardium during sustained hypodynamia

Glycolysis and the intensity of protein synthesis were studied in 140 white male rats in subcellular fractions of the myocardium during 45 day hypodynamia and hyperbaric oxygenation. Hypodynamia increased: (1) the amount of lactic acids; (2) the amount of pyruvic acid; (3) the lactate/pyruvate coefficient; and (4) the activities of aldolase and lactate dehydrogenase. Hyperbaric oxygenation was found to have a favorable metabolic effect on the animals with hypodynamia

Mechanism of disorder of plastic processes in tissue during prolonged hypokinesia

The subcellular structures of the myocardium, skeletal muscles, liver and kidneys of adult rats subjected to hypokinesia (in immobilization chambers) for 15, 30, and 45 days were studied. An anabolyser (retabolil) and vitamin D (a Ca metabolism regulator) were administered to two groups of rats. On the second week of hypokinesia, inhibition of synthesis processes was observed. Administration of retabolil increased protein synthesis both in the normal and hypokinesia-subjected rats; however, in the latter group, synthesis did not completely normalize, especially in the myocardium. Administration of vitamin D also stimulated protein synthesis, apparently by normalizing Ca tissue metabolism. The combined action of both preparations was the most effective in normalizing protein synthesis intensity. It was concluded that inhibition of synthesis is related to weakening of hormone synthesis induction and disorder of Ca metabolism

The singularly continuous spectrum and non-closed invariant subspaces

Let $\mathbf{A}$ be a bounded self-adjoint operator on a separable Hilbert space $\mathfrak{H}$ and $\mathfrak{H}_0\subset\mathfrak{H}$ a closed invariant subspace of $\mathbf{A}$. Assuming that $\mathfrak{H}_0$ is of codimension 1, we study the variation of the invariant subspace $\mathfrak{H}_0$ under bounded self-adjoint perturbations $\mathbf{V}$ of $\mathbf{A}$ that are off-diagonal with respect to the decomposition $\mathfrak{H}= \mathfrak{H}_0\oplus\mathfrak{H}_1$. In particular, we prove the existence of a one-parameter family of dense non-closed invariant subspaces of the operator $\mathbf{A}+\mathbf{V}$ provided that this operator has a nonempty singularly continuous spectrum. We show that such subspaces are related to non-closable densely defined solutions of the operator Riccati equation associated with generalized eigenfunctions corresponding to the singularly continuous spectrum of $\mathbf{B}$